This damage increases the more Orianna Attacks the same target.
After 3 seconds the mark triggers, repeating a portion of all the damage Zed dealt to the target while they were marked.
Work with your team to quickly focus him down.
If he cancels the additional Attack, he instead gains Move Speed.
Move away from his corpse to be safe.
Save your disables to finish him off.
After a few seconds, Hemoplague deals magic damage to infected enemies and heals Vladimir for each enemy Champion hit.
Try to quickly assess whether to disengage the fight or attempt to kill his allies before it goes off.