At one stage just before half-time, he played the ball directly to Michael Olise and forced Alisson into a decent save, and did not always look comfortable against the physical presence of Édouard.
It was not clear whether he meant there was an injury or he just wasn't playing well, but Matip was straight back into the starting XI.
Fabinho eventually put the ball away after it was adjudged that Diogo Jota had been fouled.
The club has won 19 League titles and currently sits in second place in the PL with 79 points, one point behind leader Manchester City FC.